Title: Multiscale Modeling of Axonal Cytoskeleton Dynamics in Disease
Speaker: Chuan Xue (Assistant Professor, Department of Mathematics, Ohio State University)
Abstract: The shape and function of an axon is dependent on its cytoskeleton, including microtubules, neurofilaments and actin. Neurofilaments accumulate abnormally in axons in many neurological disorders. An early event of such accumulation is a striking radial segregation of microtubules and neurofilaments. This segregation phenomenon has been observed for over 30 years now, but the underlying mechanism is still poorly understood. I will present a stochastic multiscale model that explained these phenomena and generated testable predictions.
This is joint work with Anthony Brown’s lab at the Ohio State University.
Ref: C. Xue, B. Shtylla, and A. Brown. A Stochastic Multiscale Model that Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases, PLoS Computational Biology, 2015.