Wednesday, April 9, 2014 (3:00 – 4:00 p.m. in Yost 306)

Title: Somatosensory Evoked Response to Median Nerve Stimulation: Review, Spatio-temporal Models, Recent MEG Results

Speaker: John C. Mosher, Ph.D. (Epilepsy Center- Cleveland Clinic)

Abstract: In response to electrical stimulation of the median nerve, the cortical regions around the central sulcus generate a widely-studied neurological response measured by electroencephalography (EEG) or magnetoencephalography (MEG). We review the anatomy of the “S1” cortical region and the continuing debate as to whether Brodmann Area 4 or 3b contributes to part of the response, ambiguous due to the underlying uncertainty of excitatory vs inhibitory post-synaptic potentials. We review the basics of spatio-temporal modeling from a linear state-space perspective and show its application to experimental data. We then present source localization results using freely available research software and sample somatosensory data sets.