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Home / Abstracts / Quantitative Life Sciences Seminar (QLSS)- April 25, 2016

Quantitative Life Sciences Seminar (QLSS)- April 25, 2016

Posted on April 19, 2016

Monday, April 25, 2016 (3:00 p.m. in Bingham 204)

Title: Psychotroctopus

Speaker: Jonathan Miller (Associate Professor, Physics and Biology Unit, Okinawa Institute for Science and Technology)

Abstract: The study of psychopharmaceuticals has undergone a resurgence as controlled clinical studies of classical neuroreceptor agonists at NIH, Johns Hopkins, and elsewhere suggest remediation of depression and addiction in humans. These reagents display a range of potentially therapeutic effects throughout the body, inviting the synthesis of derivatives that decouple them from hallucinogenic activity.

Nevertheless, the chemistry and biology of hallucinations remains elusive. Just one of many paradoxes: the 5HT-2a receptor is universally believed to be key to the mechanism, yet its strongest and most specific agonists don’t seem to yield hallucinations. Motivated by Kluver’s classic gallery of drawings by subjects experiencing closed-eye hallucinations, the physicist Jack Cowan and co-workers proposed a model wherein the observed images correspond to fundamental excitations of the cortex mapped conformally from the visual receptive field, as a representation of SO(3). His model accounts for many but not all of Kluver’s images; however, experimental confirmation in human remains out of reach. Currently, the most effective non-human test bed for this class of drug involves rodents tilting their heads in response to putative auditory hallucinations, which may not always be suitably informative.

This raises the question: what organisms aside from human report their detailed perceptions in a form we can readily understand? Conventional wisdom has it that chimps can’t draw, but parrots and chameleons also come to mind. This link to a video depicting a common inhabitant of the coral reefs visible from my window:

suggests that the octopus has evolved to report to would-be predators its detailed perception of its local environment. Remarkably little is understood about how this is achieved, and behavioral considerations confound all observations; nevertheless, promising experiments are described.

Collaborators: Jessica Gordon, Courtney Timmons, Reuven Pnini, Eric Edsinger (octopus adults and larvae). Michael Kuba, Tamar Gutnick, Ian Gleadall (octopus adults; cuttlefish). Kohei Okamoto (squid); Keishu Asada.

Page last modified: April 19, 2016